Key Dates

21 July 2013
On site registration opens

Further key dates

CFTR – Linking physiology, regulation and structure

Date & Venue

  • The Journal of Physiology
0930 - 1130
Lecture Theatre: 
Symphony Ballroom (Hyatt Regency Hotel)

Sponsored by The Journal of Physiology

The anion channel cystic fibrosis transmembrane conductance regulator (CFTR) is found in epithelial cells lining ducts and tubes throughout the body where it plays a key role in controlling the quantity and composition of epithelial secretions.  Malfunction of CFTR causes the common genetic disease cystic fibrosis (CF).  This symposium will discuss recent developments in understanding (i) the function of CFTR in different epithelial tissues, (ii) the relationship between CFTR structure and function, especially how the nucleotide-binding domains (NBDs) and regulatory domain (RD) control channel gating and (iii) the action of small-molecules that restore channel function to CF mutants.

David Sheppard
University of Bristol
United Kingdom
Jeng-Haur Chen
University of Hong Kong
Deciphering the physiological role of CFTR using pig models of cystic fibrosis
09.30 - 10.00
Michael Welsh
University of Iowa
United States
CFTR activation by specific regions of the R domain
10.00 - 10.15
Jeng-Haur Chen
University of Hong Kong
3D structural models of CFTR
10.15 - 10.45
Isabelle Callebaut
Université Pierre et Marie Curie
CFTR’s degenerate nucleotide binding site 1 probably moves during channel gating
10.45 - 11.00
Paola Vergani
University College London
United Kingdom
Employing chemical biology to define the molecular defects caused by the major cystic fibrosis mutant, F508del-CFTR
11.00 - 11.30
Christine Bear
The Hospital for Sick Children
Epithelia & Membrane Transport
Epithelia & Membrane Transport
Ion Channels