Key Dates

21 July 2013
On site registration opens

Further key dates

Intracellular signalling microdomains in heart

Date & Venue

  • The Journal of Physiology
0930 - 1130
Lecture Theatre: 
Hall 9 (The ICC)

The spatial localisation of intracellular ionic and molecular signalling is critical for co-ordinating various aspects of cell function. The proposed symposium will focus on recent research in the heart to provide an overview of five major intracellular signalling agents that can exhibit spatial compartmentalisation: Ca2+, pH, cyclic AMP, nitric oxide, and Ca2+/calmodulin. Although changes in the levels of these agents may be localised to intracellular microdomains, either diffusively or structurally, domains may nevertheless display cross-talk that converges on downstream signals, such as that for Ca2+.  Appreciating how signalling microdomains are regulated within cells is essential to our understanding of the control of the physiology and pathology of cardiac contraction, rhythm and development. By drawing together talks on a range of signalling microdomains, the symposium will assist future work on their integrated behaviour in the heart.

The symposium will have a broad appeal, not only for cardiac specialists, but also for those interested in cell signalling and integrative function. The spatial control of intracellular signalling, particularly for agents like cAMP, pH and NO,  is a young and emerging field, and therefore not without controversy. The symposium will thus be both appropriate and timely for a wide range of delegates attending IUPS.

Richard Vaughan-Jones
University of Oxford
United Kingdom
Yin Hua Zhang
Seoul National University
South Korea
Local Ca2+ signalling microdomains, and their integration within the cell
09.30 - 10.00
Tullio Pozzan
University of Padua
Compartmentation of nitric oxide synthase regulates Ca2+ signalling in heart
10.00 - 10.15
Yin Hua Zhang
Seoul National University
South Korea
Spatial coupling between pH and Ca2+ in the ventricular myocyte
10.15 - 10.45
Pawel Swietach
University of Oxford
United Kingdom
Orchestration of signaling microdomains in heart by cytoskeleton and protein scaffolds
10.45 - 11.00
Jeffrey Saucerman
University of Virginia
United States
Caveolae contribute to spatial control of cAMP within the cardiac cell
11.00 - 11.30
Sarah Calaghan
University of Leeds
United Kingdom